代表性论文
| • Tossell， K.#, Yu, X.#, Giannos, P., Anuncibay Soto, B., Nollet, M., Yustos, R., Miracca, G., Vicente, M., Miao, A., Hsieh, B., Ma, Y., Vyssotski, AL., Constandinou, T., Franks NP.*, Wisden W.* (2023) Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus. Nat. Neurosci. 26(10): 1805-1819. |
| • Yu, X. #*, Zhao, G. #, Wang, D., Wang, S., Li, R., Li, A., Wang, H., Nollet, M., Chun, Y. Y., Zhao, T., Yustos, R., Li, H., Zhao, J., Li, J., Cai, M., Vyssotski, A. L., Li, Y., Dong, H.*, Franks, N. P. *, and Wisden, W. * (2022) A specific circuit in the midbrain detects stress and induces restorative sleep. Science 377: 63-72 |
| • Yu, X. #*, Ba, W. #, Zhao, G. #, Ma, Y., Harding, E. C., Yin, L., Wang, D., Li, H., Zhang, P., Shi, Y., Yustos, R., Vyssotski, A. L., Dong, H.*, Franks, N. P. *, and Wisden, W. * (2021) Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior. Mol. Psychiatry 26: 5213-5228 |
| • Yu, X. #, Li, W. #, Ma, Y., Tossell, K., Harris, J. J., Harding, E. C., Ba, W., Miracca, G., Wang, D., Li, L., Guo, J., Chen, M., Li, Y., Yustos, R., Vyssotski, A. L., Burdakov, D., Yang, Q., Dong, H. *, Franks, N. P. *, and Wisden, W. * (2019) GABA and glutamate neurons in the VTA regulate sleep and wakefulness. Nat. Neurosci. 22: 106-119 |
| • Yu, X. #, Ye, Z. #, Houston, Catriona M., Zecharia, Anna Y., Ma, Y., Zhang, Z., Uygun, David S., Parker, S., Vyssotski, Alexei L., Yustos, R., Franks, Nicholas P. *, Brickley, Stephen G. *, and Wisden, W. * (2015) Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron 87: 164-178 |
所有论文
| • Ba, W., Nollet, M., Yin, C., Yu, X., Wong, S., Miao, A., Beckwith, EJ., Harding, EC., Ma, Y., Yustos, R., Vyssotski, AL., Wisden, W*., Franks, NP.* (2024) A REM-active basal ganglia circuit that regulates anxiety. Curr Biol. 34(15): 3301-3314. |
| • Tossell， K.#, Yu, X.#, Giannos, P., Anuncibay Soto, B., Nollet, M., Yustos, R., Miracca, G., Vicente, M., Miao, A., Hsieh, B., Ma, Y., Vyssotski, AL., Constandinou, T., Franks NP.*, Wisden W.* (2023) Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus. Nat. Neurosci. 26(10): 1805-1819. |
| • Lucaci, D., Yu, X., Chadderton, P., Wisden, W., and Brickley, S. G. * (2023) Histamine release in the prefrontal cortex excites fast-spiking interneurons while GABA released from the same axons inhibits pyramidal cells. J. Neurosci.. 11: 187-198 |
| • Yu, X. #*, Zhao, G. #, Wang, D., Wang, S., Li, R., Li, A., Wang, H., Nollet, M., Chun, Y. Y., Zhao, T., Yustos, R., Li, H., Zhao, J., Li, J., Cai, M., Vyssotski, A. L., Li, Y., Dong, H.*, Franks, N. P. *, and Wisden, W. * (2022) A specific circuit in the midbrain detects stress and induces restorative sleep. Science 377: 63-72 |
| • Harding, E. C. *, Zhang, Z., Dong, H., and Yu, X.* (2022) Editorial: Behaviors and Neural Circuits in Sleep and Sedation. Front. Neurosci. 16: 930591 |
| • Yu, X. #*, Ba, W. #, Zhao, G. #, Ma, Y., Harding, E. C., Yin, L., Wang, D., Li, H., Zhang, P., Shi, Y., Yustos, R., Vyssotski, A. L., Dong, H.*, Franks, N. P. *, and Wisden, W. * (2021) Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior. Mol. Psychiatry 26: 5213-5228 |
| • Yu, X., Franks, N. P., and Wisden, W. * (2021) Brain Clocks, Sleep, and Mood. Adv. Exp. Med. Biol. 1344: 71-86 |
| • Harding, E. C. *, Ba, W., Zahir, R., Yu, X., Yustos, R., Hsieh, B., Lignos, L., Vyssotski, A. L., Merkle, F. T., Constandinou, T. G., Franks, N. P. *, and Wisden, W. * (2021) Nitric Oxide Synthase Neurons in the Preoptic Hypothalamus Are NREM and REM Sleep-Active and Lower Body Temperature. Front. Neurosci. 15: 709825 |
| • Yu, X. #, Li, W. #, Ma, Y., Tossell, K., Harris, J. J., Harding, E. C., Ba, W., Miracca, G., Wang, D., Li, L., Guo, J., Chen, M., Li, Y., Yustos, R., Vyssotski, A. L., Burdakov, D., Yang, Q., Dong, H. *, Franks, N. P. *, and Wisden, W. * (2019) GABA and glutamate neurons in the VTA regulate sleep and wakefulness. Nat. Neurosci. 22: 106-119 |
| • Yu, X., Ma, Y., Harding, E. C., Yustos, R., Vyssotski, A. L., Franks, N. P. *, and Wisden, W. * (2019) Genetic lesioning of histamine neurons increases sleep–wake fragmentation and reveals their contribution to modafinil-induced wakefulness. Sleep 42: zsz031 |
| • Ma, Y., Miracca, G., Yu, X., Harding, E. C., Miao, A., Yustos, R., Vyssotski, A. L., Franks, N. P. *, and Wisden, W. * (2019) Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation. Curr. Biol. 29: 315-3322 |
| • Yu, X., Franks, N. P., and Wisden, W. * (2018) Sleep and Sedative States Induced by Targeting the Histamine and Noradrenergic Systems. Front. Neural Circuits 12: 4 |
| • Gelegen, C. #, Miracca, G. #, Ran, M. Z., Harding, E. C., Ye, Z., Yu, X., Tossell, K., Houston, C. M., Yustos, R., Hawkins, E. D., Vyssotski, A. L., Dong, H *. L., Wisden, W. *, and Franks, N. P. * (2018) Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation. Curr. Biol. 28: 580-587 |
| • Harding, E. C., Yu, X., Miao, A., Andrews, N., Ma, Y., Ye, Z., Lignos, L., Miracca, G., Ba, W., Yustos, R., Vyssotski, A. L., Wisden, W. *, and Franks, N. P. * (2018) A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus. Curr. Biol. 28: 2263-2273 |
| • Ye, Z., Yu, X., Houston, C. M., Aboukhalil, Z., Franks, N. P., Wisden, W., and Brickley, S. G. * (2017) Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABA(A) Receptors with Different γ Subunits. Front. Cell Neurosci. 11: 95 |
| • Jager, P. #, Ye, Z. #, Yu, X., Zagoraiou, L., Prekop, H.-T., Partanen, J., Jessell, T. M., Wisden, W., Brickley, S. G. *, and Delogu, A. * (2016) Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus. Nat. Commun. 7: 13579 |
| • Uygun, D. S., Ye, Z., Zecharia, A. Y., Harding, E. C., Yu, X., Yustos, R., Vyssotski, A. L., Brickley, S. G., Franks, N. P. *, and Wisden, W. * (2016) Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons. J. Neurosci. 36: 11171-11184 |
| • Zhang, Z. #, Ferretti, V. #, Güntan, ？., Moro, A., Steinberg, E. A., Ye, Z., Zecharia, A. Y., Yu, X., Vyssotski, A. L., Brickley, S. G., Yustos, R., Pillidge, Z. E., Harding, E. C., Wisden, W. *, and Franks, N. P. * (2015) Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists. Nat. Neurosci. 18: 553-561 |
| • Shen, N. #, Jiang, S. #, Lu, J.-M., Yu, X., Lai, S.-S., Zhang, J.-Z., Zhang, J.-L., Tao, W.-W., Wang, X.-X., Xu, N., Xue, B. *, and Li, C.-J. * (2015) The Constitutive Activation of Egr-1/C/EBPa Mediates the Development of Type 2 Diabetes Mellitus by Enhancing Hepatic Gluconeogenesis. Am. J. Pathol. 185: 513-523 |
| • Yu, X. #, Ye, Z. #, Houston, Catriona M., Zecharia, Anna Y., Ma, Y., Zhang, Z., Uygun, David S., Parker, S., Vyssotski, Alexei L., Yustos, R., Franks, Nicholas P. *, Brickley, Stephen G. *, and Wisden, W. * (2015) Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron 87: 164-178 |
| • Yu, X., Zecharia, A., Zhang, Z., Yang, Q., Yustos, R., Jager, P., Vyssotski, Alexei L., Maywood, Elizabeth S., Chesham, Johanna E., Ma, Y., Brickley, Stephen G., Hastings, Michael H., Franks, Nicholas P. *, and Wisden, W. * (2014) Circadian Factor BMAL1 in Histaminergic Neurons Regulates Sleep Architecture. Curr. Biol. 24: 2838-2844 |
| • Zecharia, A. Y., Yu, X., G？tz, T., Ye, Z., Carr, D. R., Wulff, P., Bettler, B., Vyssotski, A. L., Brickley, S. G., Franks, N. P. *, and Wisden, W. * (2012) GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. J. Neurosci. 32: 13062-13075 |
| • Yu, X. #, Shen, N. #, Zhang, M. L. #, Pan, F. Y., Wang, C., Jia, W. P., Liu, C., Gao, Q., Gao, X., Xue, B. *, and Li, C. J. * (2011) Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice. EMBO J. 30: 3754-3765 |
| • Shen, N. #, Yu, X.#, Pan, F.-Y., Gao, X., Xue, B., and Li, C.-J. * (2011) An Early Response Transcription Factor, Egr-1, Enhances Insulin Resistance in Type 2 Diabetes with Chronic Hyperinsulinism. J. Biol. Chem. 286: 14508-14515 |
| • Yu, X.#, Chen, J. #, Yu, X.., Tao, W., Jiang, F., Yin, Z., and Liu, C. * (2010) Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice. Inflamm. Res. 59: 871-877 |
| • Yu, X., Tao, W., Jiang, F., Li, C., Lin, J., and Liu, C. (2010) Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1. Am. J. Hypertens. 23: 895-903 |
