代表性论文
| • Han, D., Xiao, Q., Wang, Y., Zhang, H., Dong, X., Li, G., Kong, X., Wang, S., Song, J., Zhang, W., Zhou, J., Bi, L., Yuan, Y., Shi, L., Zhong, N., Yang, H.*, Zhou, Y.* (2023) Development of miniature base editors using engineered IscB nickase. Nat. Methods. : In Press. |
| • Tong, H., Huang, J.*, Xiao,Q., He, B., Dong, X., Liu, Y., Yang, X., Han, D., Wang, Z., Ying, W., Zhang, R., Wei, Y., Wang, X., Xu, C., Zhou, Y., Li, Y., Cai, M., Wang, Q., Xue, M., Li, G., Fang, K., Zhang, H.*, Yang, H.* (2022) High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effect. Nat. Biotechnol. : In Press. |
| • Xiao, Q., Xu, Z., Xue, Y., Xu, C., Han, L., Liu, Y., Wang, F., Zhang, R., Han, S., Wang, X., Li, G., Li, H*., Yang, H.*, Shu, Y.* (2022) Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor. Sci. Transl. Med. 14: 654. |
| • Xu, C., Zhou, Y.*, Xiao, Q., He, B., Geng, G., Wang, Z., Cao, B., Dong, X., Bai, W., Wang, Y., Wang, X., Zhou, D., Yuan, T., Huo, X., Lai, J.*, Yang, H.* (2021) Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes. Nat. Methods 18: 499-506. |
| • Gao, N., Hu, J., He, B., Ji, Z., Hu, X., Huang, J., Wei, Y., Peng, J., Wei, Y., Zhou, Y., Shen, X., Li, H., Feng, X., Xiao, Q., Shi, L., Sun, Y., Zhou, C., Zhou, H.* & Yang, H.* (2021) Endogenous promoter-driven sgRNA for monitoring the expression of low-abundance transcripts and lncRNAs. Nat. Cell Biol. 23: 99-108. |
| • Zuo, E., Sun, Y., Wei, W., Yuan, T., Ying, W., Sun, H., Yuan, L., Steinmetz, L.*, Li, Y.* & Yang H.* (2020) GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos. Nat. Protoc. 15: 3009-3029. |
| • Zuo, E.*, Sun, Y., Yuan, T., He, B., Zhou, C., Ying, W., Liu, J., Wei, W., Zeng, R., Li, Y.* & Yang H.* (2020) A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects. Nat. Methods 17: 600-604. |
| • Zhou, H.*, Su, J., Hu, X., Zhou, C., Li, H., Chen, Z., Xiao, Q., Wang, B., Wu, W., Sun, Y., Zhou, Y., Tang, C., Liu, F., Wang, L., Feng, C., Liu, M., Li, S., Zhang, Y., Xu, H., Yao, H., Shi, L. & Yang H.* (2020) Glia-to-neuron conversion by CRISPR-CasRx alleviates symptoms of neurological disease in mice. Cell 181: 590-603. |
| • Zuo, E., Sun, Y., Wei, W., Yuan, T., Ying, W., Sun, H., Yuan, L., Steinmetz, L. M.*, Li, Y.* & Yang, H.* (2019) Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos. Science 364: 289-292. |
| • Zhou, C., Sun, Y., Yan, R., Liu, Y., Zuo, E., Gu, C., Han, L., Wei, Y., Hu, X., Zeng, R., Li, Y.*, Zhou, H.*, Guo, F.* & Yang H.* (2019) Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis. Nature 517: 275-278. |
| • Zhou, H., Liu, J., Zhou, C., Gao, N., Rao, Z., Li, H., Hu, X., Li, C., Yao, X., Shen, X., Sun, Y., Wei, Y., Liu, F., Ying, W., Zhang, J., Tang, C., Zhang, X., Xu, H., Shi, L., Cheng, L., Huang, P.* & Yang, H.* (2018) In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice. Nat. Neurosci. 21: 440-446. |
| • Yao, X.*, Zhang, M., Wang, X., Ying, W., Hu, X., Dai, P., Meng, F., Shi, L., Sun, Y., Yao, N., Zhong, W., Li, Y., Wu, K., Li, W.*, Chen, Z.* & Yang, H.* (2018) Tild-CRISPR allows for efficient and precise gene knockin in mouse and human cells. Dev. Cell 45: 526-536. |
| • Zuo, E., Huo, X., Yao, X., Hu, X., Sun, Y., Yin, J., He, B., Wang, X., Shi, L., Ping, J., Wei, Y., Ying, W., Wei, W., Liu, W., Tang, C., Li, Y., Hu, J.* & Yang, H.* (2017) CRISPR/Cas9-mediated targeted chromosome elimination. Genome Biol. 18: 224. |
所有论文
| • Huang, J., He, B., Yang, X., Long, X., Wei, Y., Li, L., Tang, M., Gao, Y., Fang, Y., Ying, W., Wang, Z., Li, C., Zhou, Y., Li, S., Shi, L., Choi, S., Zhou, H.*, Guo, F.*,Yang, H.*, Wu, J.* (2024) Generation of rat forebrain tissues in mic. CELL 187(9): 2129-2142. |
| • Han, D., Xiao, Q., Wang, Y., Zhang, H., Dong, X., Li, G., Kong, X., Wang, S., Song, J., Zhang, W., Zhou, J., Bi, L., Yuan, Y., Shi, L., Zhong, N., Yang, H.*, Zhou, Y.* (2023) Development of miniature base editors using engineered IscB nickase. Nat. Methods. : In Press. |
| • Tong, H., Huang, J.*, Xiao,Q., He, B., Dong, X., Liu, Y., Yang, X., Han, D., Wang, Z., Ying, W., Zhang, R., Wei, Y., Wang, X., Xu, C., Zhou, Y., Li, Y., Cai, M., Wang, Q., Xue, M., Li, G., Fang, K., Zhang, H.*, Yang, H.* (2022) High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effect. Nat. Biotechnol. : In Press. |
| • Xiao, Q., Xu, Z., Xue, Y., Xu, C., Han, L., Liu, Y., Wang, F., Zhang, R., Han, S., Wang, X., Li, G., Li, H*., Yang, H.*, Shu, Y.* (2022) Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor. Sci. Transl. Med. 14: 654. |
| • Xu, C., Zhou, Y.*, Xiao, Q., He, B., Geng, G., Wang, Z., Cao, B., Dong, X., Bai, W., Wang, Y., Wang, X., Zhou, D., Yuan, T., Huo, X., Lai, J.*, Yang, H.* (2021) Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes. Nat. Methods 18: 499-506. |
| • Gao, N., Hu, J., He, B., Ji, Z., Hu, X., Huang, J., Wei, Y., Peng, J., Wei, Y., Zhou, Y., Shen, X., Li, H., Feng, X., Xiao, Q., Shi, L., Sun, Y., Zhou, C., Zhou, H.* & Yang, H.* (2021) Endogenous promoter-driven sgRNA for monitoring the expression of low-abundance transcripts and lncRNAs. Nat. Cell Biol. 23: 99-108. |
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| • Zuo, E.*, Sun, Y., Yuan, T., He, B., Zhou, C., Ying, W., Liu, J., Wei, W., Zeng, R., Li, Y.* & Yang H.* (2020) A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects. Nat. Methods 17: 600-604. |
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| • He, B., Peng, W., Huang, J., Zhang, H., Zhou, Y., Yang, X., Liu, J., Li, Z., Xu, C., Xue, M., Yang H.* & Huang, P.* (2020) Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver. Protein Cell 11: 518-524. |
| • Zhou, C., Hu, X., Tang, C., Liu, W., Wang, S., Zhou, Y., Zhao, Q., Bo, Q., Shi, L., Sun, X.*, Zhou, H.* & Yang H.* (2020) CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration. Natl. Sci. Rev. 7: 835-837. |
| • Zhou, H.*, Su, J., Hu, X., Zhou, C., Li, H., Chen, Z., Xiao, Q., Wang, B., Wu, W., Sun, Y., Zhou, Y., Tang, C., Liu, F., Wang, L., Feng, C., Liu, M., Li, S., Zhang, Y., Xu, H., Yao, H., Shi, L. & Yang H.* (2020) Glia-to-neuron conversion by CRISPR-CasRx alleviates symptoms of neurological disease in mice. Cell 181: 590-603. |
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