代表性论文
| • Bi, Z., Ren, M., Zhang, Y., He, S., Song, L., Li, X.*, Liu, Z.* (2024) Revisiting the Potency of Tbx2 Expression in Transforming Outer Hair Cells into Inner Hair Cells at Multiple Ages In Vivo. Journal of Neuroscience. 44 (23): e1751232024. |
| • WANG, G., Gu, Y., Liu, Z.* (2024) Deciphering the genetic interactions between Pou4f3, Gfi1, and Rbm24 in maintaining mouse cochlear hair cell survival. eLife : doi: 10.7554/eLife.90025 |
| • Chen, A., Sun, Y., Lei, Y., Li, C., Liao, S., Meng, J., Bai, Y., Liu, Z., Liang, Z., Zhu, Z., Yuan, N., Yang, H., Wu, Z., Lin, F., Wang, K., Li, M., Zhang, S., ......, Xiang, B., Li, S., Li, H., Chen, M., Wang, S., Li, M., Liu, W., Liu, X., Zhao, Q., Lisby, M., Wang, J., Fang, J., Lin, Y., Xie, Q., Liu, Z., He, J., Xu, H., Huang, W., Mulder, J., Yang, H., Sun, Y., Uhlen, M., Poo, M., Wang ,J., Yao, J*., Wei, W.*, Li, Y.*, Shen, Z.*, Liu, L.*, Liu, Z.* , Xu, X.*, Li, C.* (2023) Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex. CELL 18: 1-18. |
| • Li, X., Ren, Y., Gu, Y., Zhu, T., Zhang, Y., Li, J., Li, C., Wang, G., Song, L., Bi, Z.*, Liu, Z.* (2023) In situ regeneration of inner hair cells in the damaged cochlea by temporally regulated co-expression of Atoh1 and Tbx2. Development 150 (24): dev201888. |
| • Sun, Y. Liu, Z.* (2023) Recent advances in molecular studies on cochlear development and regeneration. Curr Opin Neurobiol. : 81:102745.（review article） |
| • Li,S., He,S., Lu,Y., Jia,S., Liu, Z.* (2023) Epistatic genetic interactions between Insm1 and Ikzf2 during cochlear outer hair cell development. Cell Rep. 42(5): 112504. |
| • Bi, Z., Li, X., Ren, M., Gu, Y., Zhu, T., Li, S., Wang, G., Sun, S., Sun, Y., Liu, Z.* (2022) Development and transdifferentiation into inner hair cells require Tbx2. Natl. Sci. Rev. : nwac156. |
| • Luo, Z., Du, Y., Li, S., Zhang, H., Shu, M., Zhang, D., He, S., Wang, G., Lu, F*., Liu, Z.* (2022) Three distinct Atoh1 enhancers cooperate for sound receptor hair cell development. PNAS. 119: e2119850119. |
| • Sun, Y., Wang, L., Zhu, T., Wu, B., Wang, G., Luo, Z., Li, C*., Wei, W*., Liu, Z.* (2022) Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages. Cell Rep. 38: 110542. |
| • Sun, S.#, Li S.#, Luo, Z.#, Ren, M., He, S., Wang, G., Liu, Z.* (2021) Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells. eLife. : doi: 10.7554/eLife.66547. |
| • Wang, G.#, Li, C.#, He, S., Liu, Z.* (2021) Mosaic CRISPR-stop enables rapid phenotyping of nonsense mutations in essential genes. Development : dev.196899. |
| • Li, C., Li X., Bi Z., Sugino K., Wang G., Zhu T., Liu, Z.,* (2020) Comprehensive transcriptome analysis of cochlear spiral ganglion neurons at multiple ages. eLife. : doi: 10.7554/eLife.50491 |
| • Zhang, H, Pan, H, Zhou, C., Wei, Y, Ying, W., Li, S., Wang, G., Li, C, Ren, Y., Li, G, Ding, X, Sun, Y., Li, GL, Song, L, Li, Y., Yang, H*, Liu, Z.* (2018) Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing. Development 145: dev.168906 |
论文
| • Zhang, D., Ren, M., Bi, Z., Gu, Y., Li, S., Wang, G., Li, X.*, & Liu, Z.* (2023) Lypd1-DTR/+: A New Mouse Model for Specifically Damaging the Type Ic Spiral Ganglion Neurons of the Cochlea. Neurosci. Bull. : 10.1007/s12264-023-01071-4. |
| • Pan, Y., Li, S., He, S., Wang, G., Li, C., Liu, Z*.,Xiang, M.* (2023) Fgf8P2A-3×GFP/+: A New Genetic Mouse Model for Specifically Labeling and Sorting Cochlear Inner Hair Cells. Neurosci. Bull. : 10.1007/s12264-023-01069-y |
| • Yang, Y., Sun, S., He, S., Liu, C., Fu, C., Tang, M., Liu, C., Sun, Y., Lam, H.*, Liu, Z.*, Tian, R.* (2022) Fully integrated on-line strategy for highly sensitive proteome profiling of 10-500 mammalian cells. Analyst. 148(1): 120-127. |
| • Sun, Y.#, Zhang, Y.#, Zhang, D.#, Wang, G., Song, L.*, Liu, Z.* (2022) In vivo CRISPR-Cas9-mediated DNA chop identifies a cochlear outer hair cell-specific enhancer. FASEB J. 36: e22233. |
| • Li, S.#, Fan, T.#, Li, C.,Wang, Y, Li, J.*, Liu, Z.* (2022) Fate-mapping analysis of cochlear cells expressing Atoh1 mRNA via a new Atoh1 3*HA-P2A-Cre knockin mouse strain Dev. Dyn. 251(7): 1156-1174. |
| • Luo, Z.#, Zhang, J.#, Qiao, L., Lu, F*., Liu, Z.* (2021) Mapping Genome-wide binding sites of Prox1 in mouse cochlea using the CUT&RUN approach. Neurosci. Bull. 37: 1703-1707 |
| • Li, X.#, Bi Z.#, Sun Y., Li C., Li Y., Liu, Z.,* (2020) In vivo ectopic Ngn1 and Neurod1 convert neonatal cochlear glial cells into spiral ganglion neurons. FASEB J. DOI: 10.1096: fj.201902118R |
| • Li, C., Wang, Y., Wang, G., Lu, Y., He, S., Sun, Y., Liu, Z.,* (2019) Fate-mapping analysis using Rorb-IRES-Cre reveals apical-to-basal gradient of Rorb expression in mouse cochlea. Dev. Dyn. DOI: 10.1002/dvdy.111 |
| • Li, X., Yu, X., Chen, X., Liu, Z., Wang, G., Li, C, Wong, E., Sham, M., Tang, J, He, J., Xiong, W, Liu, Z., Huang, P. (2019) Localization of TMC1 and LHFPL5 in auditory hair cells in neonatal and adult mice. FASEB J. DOI: 10.1096: fj.201802155RR |
| • Li, C, Shu, Y., Wang, G., Zhang, H, Lu, Y, Li, X, Li, G, Song, L, Liu, Z.* (2018) Characterizing a novel vGlut3-P2A-iCreER knockin mouse strain in cochlea. Hearing Research 364: 12-24 |
| • Yang, C.#, Fu, C.#, Sugino, K#, Liu, Z.#, Ren, Q., Liu, L., Yao, X., Lee, L., Lee, T. (2016) Transcriptomes of lineage-specific Drosophila neuroblasts profiled by genetic targeting and robotic sorting. Development 143: 411–421 |
| • Liu, Z.#, Yang, C.#, Sugino, K#, Fu, C.#, Liu, L., Yao, X., Lee, L., Lee, T. (2015) Opposing intrinsic temporal gradients guide neural stem cell production of varied neuronal fates. Science 6258: 317-320 |
| • Walters, B.#, Liu, Z.#, Crabtree, M#, Coak, E, Cox, B., Zuo, J (2014) Auditory hair cell-specific deletion of p27Kip1 in postnatal mice promotes cell-autonomous generation of new hair cells and normal hearing. J. Neurosci. 47: 15751-15763 |
| • Liu, Z., Fang, J, Dearman, J, Zhang, L., Zuo, J (2014) In vivo generation of immature inner hair cells in neonatal mouse cochleae by ectopic atoh1 expression. PLoS. One 9: e89377. |
| • Cox, B., Chai, R., Lenoir, A, Liu, Z., Zhang, L., Nguyen, D., Chalasani, K, Steigelman, K., Fang, J, Cheng, A., Zuo, J (2014) Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo. Development 141: 816-829. |
| • Liu, Z., Liu, Z., Walters, B., Owen, T, Kopan, R, Zuo, J (2013) In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea. PLoS. One 5: e64903 |
| • Liu, Z.#, Walters, B.#, Owen, T, Brimble, M., Steigelman, K., Zhang, L., Mellado Lagarde, M.,Valentine, Marcus., Yu, Yi., Cox, Brandon., Zuo, J (2012) Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium. J. Neurosci. 32: 10530-10540 |
| • Liu, Z., Dearman, J, Cox, B., Walters, B., Zhang, L., Ayrault, O, Zindy, F, Gan, L, Roussel, M., Zuo, J. (2012) Age-dependent in vivo conversion of mouse cochlear pillar and Deiters'cells to immature hair cells by Atoh1 ectopic expression. J. Neurosci. 32: 6600-6610 |
| • Cox, B., Liu, Z., Lagarde M,M., Zuo, J (2012) Conditional gene expression in the mouse inner ear using Cre-loxP. J. Assoc. Res. Otolaryngol 13: 295-322. |
| • Chai, R., Kuo, B, Wang, T, Liaw, E., Xia, A., Jan, T., Liu, Z., Taketo, M., Oghalai, J., Nusse, R, Zuo, J, Cheng, A. (2012) Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc. Natl. Acad. Sci. U. S. A. 109: 8167-72 |
| • Liu, Z., Owen, T, Fang, J, Zuo, J (2012) Overactivation of Notch1 signaling induces ectopic hair cells in the mouse inner ear in an age-dependent manner. PLoS. One 7: e34123 |
| • Liu, Z., Owen, T, Fang, J, Srinivasan, R., Zuo, J (2012) In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation. Dev. Dyn. 241: 684-96 |
| • Liu, Z., Owen, T, Zhang, L., Zuo, J (2010) Dynamic expression pattern of Sonic hedgehog in developing cochlear spiral ganglion neurons. Dev. Dyn. 239: 1674-1683 |
| • Yu, Y., Weber, T, Yamashita, T, Liu, Z., Valentine, M., Cox, B., Zuo, J (2010) In vivo proliferation of postmitotic cochlear supporting cells by acute ablation of the retinoblastoma protein in neonatal mice. J. Neurosci. 30: 5927-5936 |
| • Liu, Z., Zuo, J (2008) Cell cycle regulation in hair cell development and regeneration in the mouse cochlea. Cell Cycle 7: 2129-2133 |
